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首页> 外文OA文献 >Disclosure of HIV status and its impact on the loss in the follow-up of HIV-infected patients on potent anti-retroviral therapy programs in a (post-) conflict setting: A retrospective cohort study from Goma, Democratic Republic of Congo
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Disclosure of HIV status and its impact on the loss in the follow-up of HIV-infected patients on potent anti-retroviral therapy programs in a (post-) conflict setting: A retrospective cohort study from Goma, Democratic Republic of Congo

机译：在（冲突后）冲突局势中，在有效的抗逆转录病毒疗法计划中披露HIV状况及其对HIV感染患者的随访损失的影响：来自刚果民主共和国戈马的一项回顾性队列研究

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Background: The study aimed to identify the impact of non-disclosure of HIV status on the loss to follow-up (LTFU) of patients receiving anti-retroviral therapy. Methodology: A historic cohort of HIV patients from 2 major hospitals in Goma, Democratic Republic of Congo was followed from 2004 to 2012. LTFU was defined as not taking an ART refill for a period of 3 months or longer since the last attendance, and had not yet been classified as 'dead' or 'transferred-out'. Kaplan-Meier plots were used to determine the probability of LTFU as a function of time as inclusive of the cohort. The log-rank test was used to compare survival curves based on determinants. Cox proportional hazard modeling was used to measure predictors of LTFU from the time of treatment induction until December 15th, 2012 (the end-point). Results: The median follow-up time was 3.99 years (IQR = 2.33 to 5.59). Seventy percent of patients had shared their HIV status with others (95% CI: 66.3–73.1). The proportion of LTFU was 12% (95%CI: 9.6–14.4). Patients who did not share their HIV status (Adjusted HR 2.28, 95% CI 1.46–2.29), patients who did not live in the city of Goma (Adjusted HR 1.97, 95% CI 1.02–3.77), and those who attained secondary or higher education level (Adjusted HR 1.60, 95% CI 1.02–2.53) had a higher hazard of being LTFU. Conclusion: This study shows the relationship between the non–disclosure HIV status and LTFU. Healthcare workers in similar settings should pay more attention to clients who have not disclosed their HIV status, and to those living far from health settings where they receive medication.
机译：背景：该研究旨在确定未公开HIV状况对接受抗逆转录病毒疗法的患者的随访损失（LTFU）的影响。方法：从2004年至2012年，对刚果民主共和国戈马2家主要医院的艾滋病毒患者进行了历史性队列研究。LTFU被定义为自上次就诊以来三个月或更长时间未进行抗逆转录病毒补充药，并且尚未归类为“死”或“转出”。 Kaplan-Meier曲线用于确定LTFU随时间（包括队列）的概率。对数秩检验用于根据行列式比较生存曲线。从治疗开始到2012年12月15日（终点），使用Cox比例风险模型来测量LTFU的预测因子。结果：中位随访时间为3.99年（IQR = 2.33至5.59）。 70％的患者与他人共享艾滋病毒感染状况（95％CI：66.3–73.1）。 LTFU的比例为12％（95％CI：9.6-14.4）。不具有艾滋病毒感染状况的患者（调整后的HR 2.28，95％CI 1.46–2.29），非居住在戈马市的患者（调整后的HR 1.97，95％CI 1.02–3.77），以及达到中等或中等水平的患者较高的教育水平（调整后的HR 1.60，95％CI 1.02–2.53）有被LTFU感染的危险。结论：本研究显示了未公开的HIV状况与LTFU之间的关系。处于类似环境中的医护人员应更加注意那些尚未披露其艾滋病毒状况的服务对象，以及远离医疗场所而接受药物治疗的人。

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